HPV vaccines for prevention of cervical pre-cancer in adolescent girls and women

Authors

  • Jia Jian Li Department of Emergency Medicine, State University of New York, Downstate Medical Center, Brooklyn, New York, USA http://orcid.org/0000-0002-4446-9412
  • Jessica Stetz Department of Emergency Medicine, State University of New York, Downstate Medical Center, Brooklyn, New York, USA

DOI:

https://doi.org/10.17267/2675-021Xevidence.v1i2.2510

Keywords:

HPV, Vaccines, Cervical pre-cancer, cervical cancer, adolescent

Abstract

The evidence presented in this Cochrane meta-analysis shows the HPV vaccination confers significant benefit in preventing cervical pre-cancer. NNT of 60 for preventing one cervical pre-cancer (women 15 to 25 years old with or without HPV infection). The effect is higher for lesions associated with HPV16/18. The data also demonstrates an absence of serious adverse events. Therefore, we have assigned a color recommendation of Green (Benefit > Harm) to this vaccine.

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Author Biography

  • Jessica Stetz, Department of Emergency Medicine, State University of New York, Downstate Medical Center, Brooklyn, New York, USA
    Attending Physiican in Emergency Medicine

References

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Arbyn M, Xu L, Simoens C, Martin-Hirsch PPL. Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors. Cochrane Database of Systematic Reviews 2018, Issue 5. Art. No.: CD009069. DOI: 10.1002/14651858.CD009069.

Available at https://www.cancer.org/cancer/cancer-basics/lifetime-probability-of-developing-or-dying-from-cancer.html. Last accessed on November 30,2018

Unger E, Dillner J. Human Papillomavirus Laboratory Manual. 1st Edition. Geneva: WHO (Quality, Safety and Standards (QSS) team of the Department of Immunization, Vaccines and Biologicals), 2010.

Initiative for Vaccine Research of the Department of Immunization Vaccines and Biologicals (WHO). Human Papillomavirus (HPV) Vaccine Background Paper. World Health Organization (WHO) 2009:1–249.

Thompson SG, Sharp SJ. Explaining heterogeneity in meta- analysis: a comparison of methods. Statistics in Medicine 1999;18:2693–708.

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Available at: https://www.goodrx.com/gardasil-9?drug-name=gardasil+9. Last accessed December 1st, 2018.

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Published

10/21/2019

Issue

Vol. 1 No. 2 (2019)

Section

Critical Appraisal of Evidence

License

The authors retain copyrights, transferring to the Journal of Evidence-Based Healthcare only the right of first publication. This work is licensed under a Creative Commons Attribution 4.0 International License.

Creative Commons License

How to Cite

1.
Li JJ, Stetz J. HPV vaccines for prevention of cervical pre-cancer in adolescent girls and women. Evidence [Internet]. 2019 Oct. 21 [cited 2024 Nov. 4];1(2):112-5. Available from: https://journals.bahiana.edu.br/index.php/evidence/article/view/2510

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