Research protocol: the impact of peptic ulcers on patients with chronic obstructive pulmonary disease

Authors

DOI:

https://doi.org/10.17267/2675-021Xevidence.2022.e3984

Keywords:

COPD, Peptic ulcer, Gastroduodenal ulcer, Quality of life

Abstract

 INTRODUCTION: Among important non-communicable diseases in Brazil, Chronic Obstructive Pulmonary Disease (COPD) has been emphasized due to its association with smoking, a highly prevalent habit worldwide. Of several comorbidities strongly associated with COPD, peptic ulcer disease has been linked to smoking. The present descriptive study involving patients with COPD aimed to investigate the prevalence of gastroduodenal peptic ulcers, their impact on the quality of life of affected patients and verify associations between smoking and peptic ulcers. MATERIALS AND METHODS: The patients to be studied will be seen on an outpatient basis at the pulmonology service of the Bahia State University (UNEB). All patients will receive specific treatment for their condition after undergoing staging following the GOLD (Global Initiative for Obstructive Lung Disease) consensus and will answer validated questionnaires containing questions on health conditions, coexisting diseases, and current treatment use, as well as provide other information to assess the quality of life and flare-ups. SAMPLE: A retrospective analysis of data from 150 patients stored at the Exercise Physiology Laboratory, Department of Life Sciences (UNEB), will be retrospectively analyzed. Statistical analysis will be performed using Student's t-test, chi-squared, and multivariate regression analysis where appropriate, with results presented descriptively for the variables of interest; P values <0.05 will be considered significant. All analyzed data will be exported and analyzed by SPSS software v.26 (IBM).

Downloads

Download data is not yet available.

References

The Global Initiative for Chronic Obstructive Lung Disease. [Internet]. 2021 [cited 2021 Jul 15]. Available from: https://goldcopd.org

World Health Organization. Global Health Estimates: Life expectancy and leading causes of death and disability [Internet]. [cited 2021 Nov 7]. Available from: https://www.who.int/data/gho/data/themes/mortality-and-global-health-estimates

Menezes AMB, Jardim JR, Pérez-Padilla R, Camelier A, Rosa F, Nascimento O, et al. Prevalence of chronic obstructive pulmonary disease and associated factors: the PLATINO Study in São Paulo, Brazil. Cad Saúde Pública. 2005;21(5):1565–73. https://doi.org/10.1590/S0102-311X2005000500030

Portaria SAS/MS nº 609, de 6 de junho de 2013 (Brazil). Aprova o Protocolo Clínico e Diretrizes Terapêuticas – Doença Pulmonar Obstrutiva Crônica. [Internet]. Diário Oficial da Nação. 2013 Jun. Available from: http://www.saude.mt.gov.br/arquivo/9751

Golpe R, Martín-Robles I, Sanjuán-López P, Cano-Jiménez E, Castro-Añon O, Mengual-Macenlle N, et al. Prevalence of major comorbidities in chronic obstructive pulmonary disease caused by biomass smoke or tobacco. Respiration. 2017;94(1):38–44. https://doi.org/10.1159/000472718

Miller J, Edwards LD, Agustí A, Bakke P, Calverley PMA, Celli B, et al. Comorbidity, systemic inflammation and outcomes in the ECLIPSE cohort. Respir Med. 2013;107(9):1376–84. https://doi.org/10.1016/j.rmed.2013.05.001

Rubinsztajn R, Przyby?owski T, Grabicki M, Karwat K, Maskey-Warz?chowska M, Batura-Gabryel H, et al. Comorbidities in chronic obstructive pulmonary disease: Results of a national multicenter research project. Adv Clin Exp Med. 2019;28(3):319–24. https://doi.org/10.17219/acem/78024

Burney PGJ, Patel J, Newson R, Minelli C, Naghavi M. Global and regional trends in COPD mortality, 1990–2010. 2015;45(5):1239-47. http://dx.doi.org/10.1183/09031936.00142414

Westerik JAM, Metting EI, van Boven JFM, Tiersma W, Kocks JWH, Schermer TR. Associations between chronic comorbidity and exacerbation risk in primary care patients with COPD. Respir Res. 2017;18(1):31. https://doi.org/10.1186/s12931-017-0512-2

Raherison C, Ouaalaya EH, Bernady A, Casteigt J, Nocent-Eijnani C, Falque L, et al. Comorbidities and COPD severity in a clinic-based cohort. BMC Pulm Med. 2018;18(1):117. https://doi.org/10.1186/s12890-018-0684-7

Divo MJ, Casanova C, Marin JM, Pinto-Plata VM, De-Torres JP, Zulueta JJ, et al. COPD comorbidities network. Eur Respir J. 2015;46(3):640–50. https://doi.org/10.1183/09031936.00171614

Malfertheiner P, Chan FKL, Mccoll KEL. Peptic ulcer disease. Lancet [Internet]. 2009;374:1449–61. Available from: https://www.jvsmedicscorner.com/Medicine_files/Peptic%20ulcer%20disease%20review_1.pdf

Garrow D, Delegge MH. Risk factors for gastrointestinal ulcer disease in the US population. Dig Dis Sci. 2010;55(1):66–72. https://doi.org/10.1007/s10620-008-0708-x

Huang KW, Luo JC, Leu HB, Lin HC, Lee FY, Chan WL, et al. Chronic obstructive pulmonary disease: An independent risk factor for peptic ulcer bleeding: A nationwide population-based study. Aliment Pharmacol Ther. 2012;35(7):796–802. https://doi.org/10.1111/j.1365-2036.2012.05028.x

Huang KW, Kuan YC, Chi NF, Huang YH, Luo JC, Chien LN. Chronic obstructive pulmonary disease is associated with increased recurrent peptic ulcer bleeding risk. Eur J Intern Med. 2017;37:75–82. https://doi.org/10.1016/j.ejim.2016.09.020

Universidade Estadual da Bahia. [Internet]. [cited 2021 Nov 10]. Available from: https://portal.uneb.br/

Published

2022-04-27

How to Cite

Oliveira, K. R. M., Galliza Santana Montalvão, J. ., Camelier, A. A., & Rosa, F. W. (2022). Research protocol: the impact of peptic ulcers on patients with chronic obstructive pulmonary disease. Journal of Evidence-Based Healthcare, 4, e3984. https://doi.org/10.17267/2675-021Xevidence.2022.e3984

Issue

Section

Research Articles