Prevalence of Diabetes Mellitus among individuals with chronic kidney disease: systematic review and meta-analysis




Diabetes Mellitus, Chronic kidney disease, Systematic review, Meta-analysis, Prevalence


BACKGROUND: Diabetes Mellitus (DM) is currently considered a global epidemic, with alarming estimates for the coming years on all continents, with Chronic Kidney Disease (CKD) as one of its main consequences when a timely diagnosis is not made. OBJECTIVE: The objective of this study is to estimate the prevalence of DM among individuals diagnosed with CKD by means of a systematic review and meta-analysis. METHODS: A systematic review was carried out in the main free-access databases such as Pubmed (Medlaine), Lilacs, Scopus and Scielo. Two researchers selected the articles, extracted the data and evaluated the quality. The collected data were evaluated using a random effects model. RESULTS: Of 994 articles, 17 studies were included that looked at three continents. The group prevalence of DM among individuals with CKD (95% CI) was 29% (23-35%), with heterogeneity I2 = 99,86% and p = 0.00, which was not explained by meta-regression and subgroups. CONCLUSIONS: The present study confirmed the high prevalence of DM among individuals with CKD, especially among those with end-stage renal disease, demonstrating the need for early diagnosis and timely treatment of DM and new studies in this area, considering the social and economic impact of these diseases worldwide.


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(1) World Health Organization. Global Report on Diabetes [Internet]; Geneva: WHO; 2016. 88 p. Available from:

(2) International Diabetes Federation. Atlas de la DIABETES de la FID [Internet]; Brussels: IDF; 2015. 144 p. Available from:

(3) National Kidney Foundation. KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int Suppl [Internet]. 2013;3(1):163 p. Available from:

(4) Saran R, Li Y, Robinson B, et al. US Renal Data System 2015 Annual Data Report: epidemiology of kidney disease in the United States. Am J Kidney Dis. 2016;67(3)(1):S1-S434.

(5) United States Renal Data System (USRDS). Excerpts from 2008. Annual data report: Atlas of end-stage renal disease in the United States. Am J Kidney Dis. 2009;53(1):S1-S5).

(6) United States Renal Data System (USRDS). Excerpts from 2005. Annual data report: Atlas of end-stage renal disease in the United States. Am J Kidney Dis. 2006;47(1):1-2.

(7) Galvão TF, Pansani TSA, Harrad D. Principais Itens Para Relatar Revisões Sistemáticas e Meta-Análises: A Recomendação PRISMA. Epidemiol Serv Saúde. 2015;24(2):335–42.

(8) Loney PL, Chambers LW, Bennett KJ, Roberts JG, Stratford PW. Critical appraisal of the health research literature: prevalence or incidence of a health problem. Chronic Dis Can.1998;19(4):170-6. Cited: PMID: 10029513

(9) Sterne JA, Sutton AJ, Ioannidis JP, Terrin N, Jones DR, Lau J, et al. Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ. 2011;343:d4002.

(10) Bersan SAL, Amaral CFS, Gomes IC, Cherchiglia ML. Fatality and hospitalization in hemodialysis patients in a health plan. Rev Saúde Públ. 2013;47(3):624-33.

(11) Takaoka HH, Tecchio GT, Fukuda PE, Riella MC, Nascimento MM. Perfil de pacientes diabéticos em diálise. J BrasNefrol [Internet]. 2009;31(2):98-103. Available from:

(12) Burmeister JE, Mosmann CB, Bau R, Rosito GA. Prevalence of diabetes mellitus in chronic renal failure patients under haemodialysis in Porto Alegre, Brazil. Braz J Nephrol. 2012;34(2):117–21.

(13) Kolesnyk I, Noordzij M, Kolesnyk M, Kulyzky M, Jager KJ. Renal replacement therapy in Ukraine : epidemiology and international comparisons. Clin Kidney J. 2014;7(3):330–5.

(14) Mungrue K, Ramdial S, Barran A, Lorinda B, Bridgelal A, Gildharie S, et al. The Epidemiology of End Stage Renal Disease at a Centre in Trinidad. West IndianMed J. 2011;60(5):553–6. Cited: PMID: 22519232

(15) Cieza JM, Huamán CM, Carlos A, Gómez J, Castillo WM. Prevalencia de insuficiencia renal crónica enlaciudad de lima-perú, enero 1990. Rev Peru Epidemiol [Internet]. 1992;5(1):22–7. Available from:

(16) Peres LAB, Matsuo T, Delfino VDA, Peres CPA, Netto JHA, Ann H, et al. Increase in prevalence of diabetes mellitus as a cause of dialytic end-stage renal disease: analysis of 20 years in the west region of Paraná. Arq Bras Endocrinol Metab. 2007;51(1):111–15.

(17) Beirys RP, Constantin AR. Hipertension arterial en pacientes com insuficiência renal crónica em hemodiálises. MEDISAN [Internet]. 2009; 13(6):1029-3019. Available from:

(18) Rodrigues TC, Pecis M, Canani LH, Schreiner L, Kramer CK, Biavatti K, et al. Caracterização de Pacientes Com Diabetes Mellitus Tipo 1 do Sul do Brasil: complicações crônicas e fatores associados. Rev Assoc Med Bras. 2010;56(1):67–73.

(19) Ronqui TT, Nomoto P, Yamada SS, Baron EA. Caracterização Epidemiológica Dos Pacientes Atendidos No Ambulatório de Nefrologia Do Hospital Universitário de Maringá No Ano de 2004. Arq Ciênc Saúd UNIPAR [Internet]. 2007;11(3):205–9. Available from:

(20) Awad SM. Chronic Renal Failure in Al-Anbar of Iraq. Saudi J Kidney Dis Transpl. 2011;22(6):1280–84. Cited: PMID: 22089804

(21) Sanhueza ME, Cotera A, Elgueta L, López G, Loncon P, Macan F, Pérez F, et al. Diabetes y hemodiálisis .Caracterización de una cohorte y seguimiento a cuatroaños. Rev Méd Chile. 2008;136:279–86.

(22) Moukeh G, Yacoub R, Fahdi F, Rastam S, Albitar S. Epidemiology of Hemodialysis Patients in Aleppo City. Saudi J Kidney Dis Transplant. 2009;20(1):140–46. Cited: PMID: 19112237

(23) Barton EN, Williams W, Morgan AG, Burden RP. A Prospective Study Of Ward Referrals for Renal Disease at a Jamaican and a United Kingdom Hospital. West Indian Med J. 1996;45(4):110–2. Cited: PMID: 9033229

(24) Sarmento LR, Fernandes PFCBC, Pontes MX, Correia DBS, Chaves VCB, Carvalho CFA, et. al. Prevalence of clinically validated primary causes ofend-stagerenal disease (ESRD) in a State Capital in Northeastern Brazil. J Bras Nefrol. 2018;40(2):130-135.

(25) Diaz JFPO, López MA, Valdés RH, Machín MM, Morales MM. Registry of Chronic Kidney Disease in Primary Health Care in Cuba, 2017. Rev haban cienc méd [Internet]. 2017;17(6):1009-21. Available from:

(26) Zunigã JB, Inga JG, Onofre PC, Gómez RC, Monteverde PC. Early detection of chronic renal disease: coordinated work between primary and specialized care in anambulatory renal network of Peru. Braz. J. Nephrol. 2019;41(2):176-184.

(27) Wild S, Roglic G, Green A, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diab Care 2004;27(5):1047-53.

(28) Nieto-Martínez R, Mechanick JI, Brajkovich I, Ugel E, Risques A, Florez H, et. al. Prevalence of diabetes in three regions of Venezuela. The VEMSOLS study results. Prim Care Diabetes. 2018;12(2):126-132.

(29) Arora P, Vasa P, Brenner D, Iglar K, McFarlane P, Morrison W, et. al. Prevalence estimates of chronic kidney disease in Canada: results of a nationally representative survey. 2013;185(9):417–23.

(30) Ploth DW, Mbwambo JK, Fonner VA, Horowitz B, Zager P, Schrader R, et. al. Prevalence of CKD, Diabetes, and Hypertension in Rural Tanzania. Kidney Int Report. 2018;3(4):905–15.






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Prevalence of Diabetes Mellitus among individuals with chronic kidney disease: systematic review and meta-analysis . (2023). Journal of Evidence-Based Healthcare, 5, e4060.

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