Roadmap for the use of non-invasive brain stimulation (NIBS) for tinnitus

Authors

  • Lázaro Juliano Teixeira Prefeitura Municipal de Balneário Camboriú (Balneário Camboriú). Santa Catarina, Brazil. https://orcid.org/0000-0002-6958-6383
  • Daniela Regina Sposito Dias Oliva Instituto Paranaense de Otorrinolaringologia (Londrina). Paraná, Brazil. https://orcid.org/0009-0008-2779-9429
  • Catarina Costa Boffino Universidade Municipal de São Caetano do Sul (São Caetano do Sul). São Paulo, Brazil. https://orcid.org/0000-0001-8280-6320
  • Lidiane Maria de Brito Macedo Ferreira Universidade Federal do Rio Grande do Norte (Natal). Rio Grande do Norte, Brazil. https://orcid.org/0000-0002-2191-8641
  • Adriana Leico Oda Neurovitali (São Paulo). São Paulo, Brazil. Neuroqualis (São Paulo). São Paulo, Brazil. https://orcid.org/0000-0001-8135-2937
  • Lívia Shirahige Instituto de Neurociência Aplicada (Recife). Pernambuco, Brazil. Núcleo de Assistência e Pesquisa em Neuromodulação - NAPeN network (Recife). Pernambuco, Brazil. https://orcid.org/0000-0002-3331-0596

DOI:

https://doi.org/10.17267/2965-3738bis.2025.e6483

Keywords:

Clinical Protocol, Tinnitus, Transcutaneous Electric Nerve Stimulation, Systematic Review

Abstract

INTRODUCTION: The demand for effective interventions for tinnitus remains high, with low evidence in conventional therapeutic methods and non-invasive brain stimulation (NIBS). NIBS techniques are an important new alternative for the treatment of tinnitus, in different application modalities such as repetitive transcranial magnetic stimulation (rTMS) and transcranial electrical stimulation (tES). OBJECTIVE: The objective of this project is, therefore, to translate the available evidence into safe, personalized clinical practices that are effectively grounded in scientific data through the development of a roadmap for the use of NIBS in tinnitus. METHODS AND MATERIAL: Study protocol of a structured roadmap for NIBS use for tinnitus is proposed here based on systematic reviews with meta-analysis. The work team will proceed with that in a period of nine months of work to publish it.

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References

1. Langguth B. Non-invasive neuromodulation for tinnitus. J Audiol Otol. 2020;24(3):113–8. http://doi.org/10.7874/jao.2020.00052

2. Rossi S, Mandalà T. Tinnitus: a non-invasive neuromodulatory perspective. Curr Treat Options Neurol. 2024;26(6):421–31. http://doi.org/10.1007/s11940-024-00802-w

3. Alashram AR. The efficacy of transcranial random noise stimulation in treating tinnitus: a systematic review. Eur Arch Otorhinolaryngol. 2024;281(12):6239–52. http://doi.org/10.1007/s00405-024-08858-9

4. Soleimani R, Jalali MM, Hasandokht T. Therapeutic impact of repetitive transcranial magnetic stimulation (rTMS) on tinnitus: a systematic review and meta-analysis. Eur Arch Otorhinolaryngol. 2016;273(7):1663–75. http://doi.org/10.1007/s00405-015-3642-5

5. Chen JJ, Zeng BS, Wu CN, Stubbs B, Carvalho AF, Brunoni AR, et al. Association of central noninvasive brain stimulation interventions with efficacy and safety in tinnitus management: a meta-analysis. JAMA Otolaryngol Head Neck Surg. 2020;146(9):801–9. http://doi.org/10.1001/jamaoto.2020.1497

6. Martins ML, Souza DS, Cavalcante MEOB, Barboza HN, Medeiros JF, Andrade SMMS, et al. Effect of transcranial direct current stimulation for tinnitus treatment: a systematic review and meta-analysis. Neurophysiol Clin. 2022;52(1):1–16. https://doi.org/10.1016/j.neucli.2021.12.005

7. Chen S, Du M, Wang Y, Li Y, Tong B, Qiu J, et al. State of the art: non-invasive electrical stimulation for the treatment of chronic tinnitus. Ther Adv Chronic Dis. 2023;14:e20406223221148061. http://doi.org/10.1177/20406223221148061

8. Fernández-Hernando D, Fernández-de-las-Peñas C, Machado-Martín A, Angulo-Díaz-Parreño S, García-Esteo FJ, Mesa-Jiménez JA. Effects of non-invasive neuromodulation of the vagus nerve for management of tinnitus: a systematic review with meta-analysis. J Clin Med. 2023;12(11):3673. http://doi.org/10.3390/jcm12113673

9. Barreto IG, Nogueira MG, Bortolotti JT, Neubauer MO, Monte-Silva K, Shirahige L, et al. Decision-making for non-invasive neuromodulation prescription in the treatment of generalized anxiety disorder: a roadmap proposal. Brain Imaging Stimul. 2025;4:e6258. http://doi.org/10.17267/2965-3738bis.2025.e6258

10. Rohatgi A. WebPlotDigitizer [Internet]. Automeris.io; 2010. Available from: https://apps.automeris.io/wpd/

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Published

11/14/2025

Issue

Vol. 4 (2025)

Section

Research Protocols

License

Copyright (c) 2025 Lázaro Juliano Teixeira, Daniela Regina Sposito Dias Oliva, Catarina Costa Boffino, Lidiane Maria de Brito Macedo Ferreira, Adriana Leico Oda, Lívia Shirahige

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

This work is licensed under a Creative Commons Attribution 4.0 International License.

Creative Commons License

How to Cite

1.
Teixeira LJ, Oliva DRSD, Boffino CC, Ferreira LM de BM, Oda AL, Shirahige L. Roadmap for the use of non-invasive brain stimulation (NIBS) for tinnitus. Brain Imaging and Stimul. [Internet]. 2025 Nov. 14 [cited 2025 Dec. 5];4:e6483. Available from: https://journals.bahiana.edu.br/index.php/brain/article/view/6483