Efeito do treinamento aeróbico na depressão e função tireoidiana em mulheres com hipotireoidismo tratado

Autores

DOI:

https://doi.org/10.17267/2238-2704rpf.2023.e5254

Palavras-chave:

Hipotireoidismo, Sintomas Depressivos, Exercício

Resumo

INTRODUÇÃO: O hipotireoidismo é comumente associado à depressão e à lentidão da atividade mental. OBJETIVOS: A presente investigação teve como objetivo investigar o efeito do treinamento aeróbico na depressão e na função tireoidiana em mulheres com hipotireoidismo tratado. MÉTODOS E MATERIAIS: Trinta mulheres diagnosticadas com hipotireoidismo primário que foi regulado e acompanhado por níveis leves a moderados de depressão completaram um teste de exercício controlado randomizado de 12 semanas envolvendo dois grupos iguais: aeróbico (n = 15) e controle (n = 15). O grupo de exercício realizou três sessões de exercício aeróbico por semana em intensidade baixa a moderada por 12 semanas consecutivas, enquanto o grupo de controle não realizou nenhuma intervenção de exercício durante a mesma duração. No início e pós-intervenção, o escore do Inventário de Depressão de Beck (BDIS), hormônio estimulante da tireoide (TSH) e tiroxina livre (T4) foram avaliados. RESULTADOS: O grupo de exercícios apresentou melhorias significativas em BDIS, TSH e T4 livre em comparação com a linha de base (p < 0,05) com alteração insignificante no grupo de controle (p > 0,05). Em comparação com o controle, todos os itens medidos diferiram significativamente em favor do grupo de treinamento aeróbico. CONCLUSÃO: Em mulheres com hipotireoidismo tratado, o treinamento aeróbico pode minimizar os sintomas depressivos e melhorar a função da tireoide.

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Referências

(1) Chaker L, Bianco AC, Jonklaas J, Peeters RP. Hypothyroidism. Lancet. 2017;390(10101):1550-62. https://doi.org/10.1016/s0140-6736(17)30703-1

(2) Bereda G. Definition, Causes, Pathophysiology, and Management of Hypothyroidism. Mathews J Pharma Sci. 2023;7(1):14. https://doi.org/10.30654/MJPS.10014

(3) Chiovato L, Magri F, Carlé A. Hypothyroidism in Context: Where We've Been and Where We're Going. Adv Ther. 2019;36(suppl 2):47-58. https://doi.org/10.1007%2Fs12325-019-01080-8

(4) Tayde PS, Bhagwat NM, Sharma P, Sharma B, Dalwadi PP, Sonawane A, et al. Hypothyroidism and Depression: Are Cytokines the Link?. Indian J Endocrinol Metab. 2017;21(6):886-92. https://doi.org/10.4103%2Fijem.IJEM_265_17

(5) Whybrow PC, Prange AJ Jr, Treadway CR. Mental changes accompanying thyroid gland dysfunction. A reappraisal using objective psychological measurement. Arch Gen Psychiatry. 1969;20(1):48-63. https://doi.org/10.1001/archpsyc.1969.01740130050004

(6) Cleare AJ, McGregor A, O'Keane V. Neuroendocrine evidence for an association between hypothyroidism, reduced central 5-HT activity and depression. Clin Endocrinol. 1995;43(6):713-9. https://doi.org/10.1111/j.1365-2265.1995.tb00540.x

(7) Ge JF, Xu YY, Qin G, Cheng JQ, Chen FH. Resveratrol Ameliorates the Anxiety- and Depression-Like Behavior of Subclinical Hypothyroidism Rat: Possible Involvement of the HPT Axis, HPA Axis, and Wnt/β-Catenin Pathway. Front Endocrinol. 2016;7:44. https://doi.org/10.3389/fendo.2016.00044

(8) Kotkowska Z, Strzelecki D. Depression and Autoimmune Hypothyroidism-Their Relationship and the Effects of Treating Psychiatric and Thyroid Disorders on Changes in Clinical and Biochemical Parameters Including BDNF and Other Cytokines-A Systematic Review. Pharmaceuticals. 2022;15(4):391. https://doi.org/10.3390/ph15040391

(9) Iosifescu DV, Bolo NR, Nierenberg AA, Jensen JE, Fava M, Renshaw PF. Brain bioenergetics and response to triiodothyronine augmentation in major depressive disorder. Biol Psychiatry. 2008;63(12):1127-34. https://doi.org/10.1016/j.biopsych.2007.11.020

(10) Bauer M, Berman SM, Schlagenhauf F, Voytek B, Rasgon N, Mandelkern MA, et al. Regional cerebral glucose metabolism and anxiety symptoms in bipolar depression: effects of levothyroxine. Psychiatry Res. 2010;181(1):71-6. https://doi.org/10.1016/j.pscychresns.2009.07.001

(11) Zhou Y, Wang X, Zhao Y, Liu A, Zhao T, Zhang Y, et al. Elevated Thyroid Peroxidase Antibody Increases Risk of Post-partum Depression by Decreasing Prefrontal Cortex BDNF and 5-HT Levels in Mice. Front Cell Neurosci. 2017;10:307. https://doi.org/10.3389/fncel.2016.00307

(12) Bortolotto VC, Pinheiro FC, Araujo SM, Poetini MR, Bertolazi BS, Paula MT, et al. Chrysin reverses the depressive-like behavior induced by hypothyroidism in female mice by regulating hippocampal serotonin and dopamine. Eur J Pharmacol. 2018;822:78-84. https://doi.org/10.1016/j.ejphar.2018.01.017

(13) Jonklaas J, Bianco AC, Bauer AJ, Burman KD, Cappola AR, Celi FS, et al. Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement. Thyroid. 2014;24(12):1670-751. https://doi.org/10.1089/thy.2014.0028

(14) Sawka AM, Gerstein HC, Marriott MJ, MacQueen GM, Joffe RT. Does a combination regimen of thyroxine (T4) and 3,5,3'-triiodothyronine improve depressive symptoms better than T4 alone in patients with hypothyroidism? Results of a double-blind, randomized, controlled trial. J Clin Endocrinol Metab. 2003;88(10):4551-5. https://doi.org/10.1210/jc.2003-030139

(15) Bai S, Chen L, Zhao L. Research on the evolution of movement difficulty of competitive aerobics based on digital image processing. J Intell Fuzzy Syst. 2021. Available from: https://www.researchgate.net/publication/352050813_Research_on_the_evolution_of_movement_difficulty_of_competitive_aerobics_based_on_digital_image_processing

(16) Todorova V, Dolinsky B, Pasichna T. Improving the content of choreographic training in sports aerobics at the stage of specialized basic training. Science and Education. 2020;(1):60-5. https://doi.org/10.24195/2414-4665-2020-1-9

(17) Bansal N, Kotwal N, Kumar S. Aerobic vs Resistance Exercise—An Endocrine Perspective. J Med Acad. 2020;3(1):7-10. https://doi.org/10.5005/jp-journals-10070-0057

(18) Abbas MAM, El Badrey SM, ElDeeb AM, Sayed AM. Effect of aerobic exercises on the thyroid hormones in treated hypothyroid pregnant women. Adv Pharm Edu Res [Internet]. 2019;9(4):49-53. Available from: https://japer.in/article/effect-of-aerobic-exercises-on-the-thyroid-hormones-in-treated-hypothyroid-pregnant-women

(19) Askari J, Saberi-Kakhki A, Taheri H, Yassini SM. The Effect of Aerobic Exercise on Different Symptoms of Depression: An Investigation of Psychological Mechanisms of Stress and Coping. Open J Med Psychol. 2017;6(2):86-102. https://doi.org/10.4236/ojmp.2017.62007

(20) Baloch Z, Carayon P, Conte-Devolx B, Demers LM, Feldt-Rasmussen U, Henry JF, et al. Laboratory support for the diagnosis and monitoring of thyroid disease. Thyroid. 2003;13(1):3-126. https://doi.org/10.1089/105072503321086962

(21) Nuttall FQ. Body Mass Index: Obesity, BMI, and Health: A Critical Review. Nutr Today. 2015;50(3):117-28. https://doi.org/10.1097/nt.0000000000000092

(22) Svenaeus F. Diagnosing mental disorders and saving the normal. Med Health Care Philos. 2014;17(2):241-4. https://doi.org/10.1007/s11019-013-9529-6

(23) Wang YP, Gorenstein C. Psychometric properties of the Beck Depression Inventory-II: a comprehensive review. Braz J Psychiatry. 2013;35(4):416-31. https://doi.org/10.1590/1516-4446-2012-1048

(24) Beck AT, Steer RA, Brown GK. BDI-II, Beck Depression Inventory: Manual. San Antonio: TX Psychological Corporation; 1996.

(25) Fawzi MH, Fawzi MM, Abu-Hindi W. Arabic version of the Major Depression Inventory as a diagnostic tool: reliability and concurrent and discriminant validity. East Mediterr Health J. 2012;18(4):304-10. https://doi.org/10.26719/2012.18.4.304

(26) Bruce RA. Exercise testing of patients with coronary heart disease. Principles and normal standards for evaluation. Ann Clin Res. 1971;3(6):323-32. Cited: PMID: 5156892

(27) Bongers BC, Vries SI, Obeid J, van Buuren S, Helders PJM, Takken T. The Steep Ramp Test in Dutch white children and adolescents: age- and sex-related normative values. Phys Ther. 2013;93(11):1530-9. https://doi.org/10.2522/ptj.20120508

(28) Holtgrefe, K. Principles of aerobic exercises. In: Kisner C, Colby LA. Therapeutic exercise, Foundations and Techniques. 6th. ed. Philadelphia: F. A. Davis Company; 2012. p. 247-251.

(29) Bodegard J, Erikssen G, Bjørnholt JV, Gjesdal K, Liestøl K, Erikssen J. Reasons for terminating an exercise test provide independent prognostic information: 2014 apparently healthy men followed for 26 years. Eur Heart J. 2005;26(14):1394-401. https://doi.org/10.1093/eurheartj/ehi278

(30) Rani S, Maharana S, Metri KG, Bhargav H, Nagaratna R. Effect of yoga on depression in hypothyroidism: A pilot study. J Tradit Complement Med. 2021;11(4):375-80. https://doi.org/10.1016/j.jtcme.2021.01.001

(31) Rahman MH, Ali MY. The Relationships between Thyroid Hormones and the Brain Serotonin (5-HT) System and Mood: Of Synergy and Significance in the Adult Brain- A Review. Faridpur Med Coll J. 2015;9(2):98-101. https://doi.org/10.3329/fmcj.v9i2.25684

(32) Ezzat W, Abd-El Hamid MS. Aerobic Exercise Mediated Increase in BDNF Expression Ameliorates Depression in Propylthiouracil-Induced Hypothyroidism in Adult Rats. Journal of Affective Disorders Reports. 2021;6:100268. https://doi.org/10.1016/j.jadr.2021.100268

(33) Fernandez SP, Muzerelle A, Scotto-Lomassese S, Barik J, Gruart A, Delgado-García JM, et al. Constitutive and Acquired Serotonin Deficiency Alters Memory and Hippocampal Synaptic Plasticity. Neuropsychopharmacology. 2017;42(2):512-23. https://doi.org/10.1038/npp.2016.134

(34) Sigwalt AR, Budde H, Helmich I, Glaser V, Ghisoni K, Lanza S, et al. Molecular aspects involved in swimming exercise training reducing anhedonia in a rat model of depression. Neuroscience. 2011;192:661-74. https://doi.org/10.1016/j.neuroscience.2011.05.075

(35) Wang X, Cai ZD, Jiang WT, Fang YY, Sun WX, Wang X. Systematic review and meta-analysis of the effects of exercise on depression in adolescents. Child Adolesc Psychiatry Ment Health. 2022;16(1):16. https://doi.org/10.1186/s13034-022-00453-2

(36) Rao UT, Noronha JA, Adiga K. Effect of aerobic exercises on depressive symptoms, anxiety, self-esteem, and quality of life among adults with depression. Clin Epidemiology Glob Health. 2020;8(4):1147-51. https://doi.org/10.1016/j.cegh.2020.04.006

(37) Altaye KZ, Mondal S, Legesse K, Abdulkedir M. Effects of aerobic exercise on thyroid hormonal change responses among adolescents with intellectual disabilities. BMJ Open Sport Exerc Med. 2019;5(1):e000524. https://doi.org/10.1136%2Fbmjsem-2019-000524

(38) Fathi M, Mosaferi Ziaaldini M, Khairabadi S, Hejazi K. Effect of aerobic exercise on thyroid hormones and quality of life in obese postmenopausal women. Medical Laboratory Journal 2018;12(6):5-11. http://dx.doi.org/10.29252/mlj.12.6.5

(39) Krotkiewski M, Sjöström L, Sullivan L, Lundberg PA, Lindstedt G, Wetterqvist H, et al. The effect of acute and chronic exercise on thyroid hormones in obesity. Acta Med Scand. 1984;216(3):269-75. https://doi.org/10.1111/j.0954-6820.1984.tb03804.x

(40) Onsori, M, Galedari, M. Effects of 12 weeks aerobic exercise on plasma level of TSH and thyroid hormones in sedentary women. Euro J Sports Exerc Sci [Internet]. 2015;4(1):45-9. Available from: https://www.researchgate.net/publication/319591512_Effects_of_12_weeks_aerobic_exercise_on_plasma_level_of_TSH_and_thyroid_hormones_in_sedentary_women

(41) Sullo A, Brizzi G, Maffulli N. Deiodinating activity in the brown adipose tissue of rats following short cold exposure after strenuous exercise. Physiol Behav. 2003;80(2-3):399-403. https://doi.org/10.1016/j.physbeh.2003.09.005

Publicado

06.09.2023

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1.
Gayar SLE. Efeito do treinamento aeróbico na depressão e função tireoidiana em mulheres com hipotireoidismo tratado. Rev Pesq Fisio [Internet]. 6º de setembro de 2023 [citado 23º de novembro de 2024];13:e5254. Disponível em: https://journals.bahiana.edu.br/index.php/fisioterapia/article/view/5254

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