NEURODYNAMIC MOBILIZATION AND PERIPHERAL NERVE REGENERATION: LITERATURE REVIEW

Authors

  • Emyle Martins Lima
  • D. M. Cavalcante
  • Iasmyn Adelia Victor Fernandes de Oliveira
  • Eulália Silva dos Santos Pinheiro
  • Abrahão Fontes Baptista
  • Ana Maria Blanco Martinez

DOI:

https://doi.org/10.17267/2238-2704rpf.v3i1.108

Keywords:

Nerve crush, Rehabilitation, Sciatic nerve, Neurodynamic, Physical therapy techniques, Rats.

Abstract

Introduction: The neurodynamicmobilization may be indicated in a number of conditions affecting the peripheral nerve, but little is known about its regenerative effects. Objectives: Describe how the neurodynamic mobilization may interfere with the mechanical and physiological properties of the peripheral nerve. Methods: This narrative review included all articles registered form 1973 to 2012in PubMed, written in Portuguese and English languages, and books involving this topic.  Discussion and conclusion: After a peripheral nerve injury a series of events can influence regeneration, including the axonal transport and movement of fluids,the mechanical loads applied to the neural tissue and the type of injury. These aspects may be influenced by neurodynamic mobilizations.  The dose, including the magnitude of the load, speed and time are factors that tension should be adjusted for optimum response, since both overload, and immobility or hypomobility may have negative effects on the recovery.

Downloads

Download data is not yet available.

Author Biographies

  • Emyle Martins Lima
    Graduada em Fisioterapia pela Escola Bahiana de Medicina e Saúde Pública- EBMSP (2010). Mestre em Medicina e Saúde pela Universidade Federal da Bahia. Formação no método Pilates(2010) e Reeducação Postural Global (2012). Pesquisador do Laboratório de Eletroestimulação Funcional da Universidade Federal da Bahia-UFBA. Tem experiência na área clínica e em pesquisa, com foco principalmente em Dor e Regeneração Nervosa Periférica. Experiencia Acadêmica na disciplina de Anatomia Humana pela Universidade Federal da Bahia
  • D. M. Cavalcante

    Programa de Pós-graduação em Medicina e Saúde, Faculdade de Medicina, Universidade Federal da Bahia. Laboratório de Eletroestimulação Funcional, Departamento de Biomorfologia, Universidade Federal da Bahia

  • Iasmyn Adelia Victor Fernandes de Oliveira

    Laboratório de Eletroestimulação Funcional, Departamento de Biomorfologia, Universidade Federal da Bahia

  • Eulália Silva dos Santos Pinheiro

    Programa de Pós-graduação em Medicina e Saúde, Faculdade de Medicina, Universidade Federal da Bahia. Laboratório de Eletroestimulação Funcional, Departamento de Biomorfologia, Universidade Federal da Bahia

  • Abrahão Fontes Baptista
    Graduado em fisioterapia pelo Instituto Brasileiro de Medicina de Reabilitação (1992), com especialização em docência do ensino superior pela Faculdade Béthèncourt da Silva (1993), aperfeiçoamento em técnica operatória e cirurgia experimental pela Escola Bahiana de Medicina e Saúde Pública (1999), mestrado (2005) e doutorado (2007) em Ciências Morfológicas pela Universidade Federal do Rio de Janeiro. Tem experiência na área clínica, de educação e em pesquisa, tendo como principais interesses os tópicos dor, lesão e regeneração nervosa periférica, interação de campos eletromagnéticos com tecidos biológicos e desenvolvimento de dispositivos de tecnologia assistiva. Atualmente é professor adjunto II do Departamento de Biomorfologia da Universidade Federal da Bahia, pesquisador colaborador do Centro de Pesquisas Gonçalo Moniz - FIOCRUZ e do Centro de Referência em HTLV da Escola Bahiana de Medicina e Saúde Pública. É responsável pelo Laboratório de Eletroestimulação Funcional da UFBA, professor do quadro permanente do Programa de Pós-graduação em Medicina e Saúde da UFBA, professor colaborador dos Programas de Pós-graduação em Medicina e Saúde e Tecnologia e Saúde da EBMSP, bolsista pesquisador na empresa DTI 1B (FAPESB) da IMAGO Desenvolvimento de Produtos e membro do iNCT Ciência, Inovação e Tecnologia em Saúde
  • Ana Maria Blanco Martinez

    Médica pela Universidade Federal da Bahia (1978), realizou residência em Anatomia Patológica no Hospital Universitário Professor Edgar Santos (UFBa) em 1979 e concluiu Doutorado em Neurociências na Universidade de Londres, em 1984. Atualmente é Professora Associada IV no Instituto de Ciências Biomédicas da Universidade Federal do Rio de Janeiro. Entre os anos de 1995-1996 fez Pós - Doutorado na Universidade de Rochester, EUA, também na área de Neurociências. Participa dos Programas de Pós-Graduação em Ciências Morfológicas (UFRJ,) desde a sua fundação, e em Anatomia Patológica (UFRJ) onde atua como Professora orientadora na área de Degeneração e Regeneração do Sistema Nervoso. Já orientou 23 teses de Mestrado e 12 de Doutorado. Publicou até o momento 70 trabalhos científicos, todos em Revistas Indexadas. (Texto informado pelo autor)


References

Shacklock M. Neurodinâmicageral. In: Elsevier BH-, editor. Neurodinâmica clínica: uma nova abordagem do tratamento da dor e da disfunção musculo esquelética. Rio de Janeiro; 2006. p. 16.

Stoll G, Müller HW. Nerve injury, axonal degeneration and neural regeneration: basic insights. Brain Pathology. 1999;9:313-25.

Allodi, I., Udina E., and Navarro, X.Specificity of peripheral nerve regeneration: interactions at the axon level. ProgNeurobiol 2012;98:16-37.

MartinezAM, Ribeiro LC.Ultrasturctural localization of calcium in peripheral nerve fibers undergoing Wallerian-Degeneration: an oxalate-pyroantimoniate and X-ray microanalysis study. J SubmicroscCytolPathol.1998;30:451-8.

McCaig CDR, RajnicekAM, SONG B, Zhao M. Has electric growth cone guidance found its potential? Trends in Neurosciences. 2002;25(7):354-9.

Stoll G, Müller HW. Nerve injury, axonal degeneration and neural regeneration: basic insights. Brain Pathology. 1999;9:313-25.

Stewart HJC, Curtis R,Jessen, KR,Mirsky R. TGF-beta and cAMP regulate GAP-43 expression in Schwann cells and reveal the association of this protein with the trans-Golgi network. JNeurosci. 1995;7(8):1761-72.

Fu SY, Gordon T.The cellular and molecular basis of peripheral nerve regeneration. . MolNeurobiol. 1997;14(12):67-116.

Squecco R, Kerm H, Biral D, Rossini K, FranciniF.Mechano-sensitivity of normal and long term denervated soleus muscle of the rat. Neurol Res. 2008;30(2):155-9.

Goran Lundborg. Acute nerve compression. In: Elsevier, editor. Nerve Injury and Repair: Rgeneration, Reconstruction, and Cortical Remodeling. Second Edition ed. USA1988.

Butler DS. Mobilização do Sistema Nervoso. São Paulo: Manolle; 2003.

Valero-Cabré A, Navarro X. Functional impact of axonal misdirection after peripheral nerve injuries followed by graft or tube repair. J Neurotrauma. 2002;19(11):1475-85.;19(11):1475-85.

GoranLundborg. L. Nerve Injury and Repair: Regeneration, Reconstruction and Cortical. 2nd ed. 1988.

GoranLundborg , Richard P. Nerve injury and repair – a challenge to the plastic brain. J PeripherNerv Syst. 2003;8(4):209-26.

Michaelevski I. Axonal Transport Proteomics Reveals Mobilization of Translation Machinery to the Lesion Site in Injured Sciatic Nerve, Molecular & Cellular Proteomics. The American Society for Biochemistry and Molecular Biology. 2010.

Hammond C. Cellular and Molecular Neurobiology. 2nd ed. Academic Press EUA: Califórnia; 2001. p. 481.

Morris JB, Davies WR. Molecular Biology of the Neuron. 2nd ed. EUA: New York; 2004. 499 p.

Alberts B. Molecular Biology of the Cell. 5ª ed 1999.

Walsh MT. Upper limb neural tension testing and mobilization. Fact, fiction, and a practical approach. Journal of hand therapy: official journal of the American Society of Hand Therapists. 2005;18(2):241-58. Epub 2005/05/14.

GoranLundborg, Goteborg Swwden. structure and function or the intraneuralmicrovessels as related to trauma, edema formation, and nerve function. J Bone Joint Surg Am 1975;57:938 -48.

Richard FE, Wayne AH, Peter JM. Comparison of Longitudinal Sciatic Nerve Movement withDiferent Mobilization Exercises: An In Vivo Study Utilizing Ultrasound Imaging. J Orthop Sports PhysTher 2012. 2012;42(8):667-75.

Rydevik BL, Kwan MK, Myers RR, Brown RA, Triggs KJ, Woo SL and GarfinSR.An in vitro mechanical and histological study of acute stretching on rabbit tibial nerve. J Orthop Res. 1990;8:694-701.

Mahmud A, Ismail M, Álvaro RCM, Irênio G, Jefferson B, Daniel BN. Relationship between adverse neural tension and nerve conduction studies in patients with symptoms of the carpal tunnel syndrome. ArqNeuropsiquiatr. 2006;64(2-A):277-82.

Mackinnon SE. Pathophysiology of nerve compression. Hand Clin. 2002;18:231-341.

LundborgG,RydevikB. Effects of stretching the tibial nerve of the rabbit: a preliminary study of the intraneural circulation and the barrier function of the perineurium. J Bone Joint Surg Br. 1973;55(1):390-401.

Brown R, Cynthia LB, Kerry KG, Jean-Michel B, Philip SS, Roger CJ, Michael PS. The effects of stretching upon conduction properties in the rabbit tibial nerve at the ankle: an unembalmed cadaveric study. J Man ManipTher. 2011;19 (1).

Dilley A, Lynn B, Pang SJ.Pressure and stretch mechanosensitivity of peripheral nerve fibres following local inflammation of the nerve trunk.Pain. 2005;117(3):462-72.

Peter JD, Michael AG, Graham ML. An in vivo study of peripheral nerves in continuity: biomechanical and physiological responses to elongation. J Orthop Res. 2002;20:370-5.

Wall EJ, Massie JB, Kwan MK. Experimental stretch neuropathy: changes in nerve conduction under tension. J Bone Joint Surg Br. 1992;74-B:126-9.

Take O,MatuzakiH, Hoshino M. Pathology and pressure of the nerve root at the herniated site during straight-leg-raising test: lumbar disc herniation. J JpnOrthopAssoc 1989;63:S1008.

Fleming P,LenehanB, O_Rourke S. Strain on the human sciatic nerve in vivo during movement of the hip and knee. J Bone Joint Surg Br. 2003;85B:363-5.

Coppieters MW, AlshamiAM. Longitudinal Excursion and Strain in the Median Nerve during Novel Nerve Gliding Exercises for Carpal Tunnel Syndrome. Journal of orthopaedicresearch : official publication of the Orthopaedic Research Society. 2007;25:972-80.

Schmidhammer R, ZandiehS,HopfR,MiznerI,PelinkaLE,KroepflA et al. Alleviated tension at the repair site enhances functional regeneration: the effect of full range of motion mobilization on the regeneration of peripheral nerves--histologic, electrophysiologic, and functional results in a rat model. J Trauma. 2004;56(3):571-84. Epub 2004/05/07.

RozmarynLM,Dovelle S, Rothman ER, Gorman K, OlveyKM,Bartko JJ. Nerve and tendon gliding exercises and the conservative management of carpal tunnel syndrome. Journal of hand therapy: official journal of the American Society of Hand Therapists. 1998;11(3):171-9.

Myers RR, Murakami H, Powell HC. Reduced nerve blood flow in edematous neuropathies: a biomechanical mechanism.Microvasc Res. 1986;32(2):145-51.

Sunderland IRP, Brenner MJ, Singham J, Rickman RS, Hunter DA and Mackinnon SE. Effect of tension on nerve regeneration in rat sciatic nerve transection model. Ann Plast Surg. 2004; 53(4):382-7.

Boyd SB, Puttlitz C, GanJ,Topp KS. Strain and excursion in the rat sciatic nerve during a modified straight leg raise are altered after traumatic nerve injury. Journal of orthopaedicresearch : official publication of the Orthopaedic Research Society. 2005;23:764-70.

Singh A, Kallakuti S, Chen C, and Cavanaugh JM. Abstract. Structural and Functional Changes in Nerve Roots Due to Tension at Various Strains and Strain Rates: An In-Vivo Study. J Neurotrauma2009;26:627-40.

Ogata K, Naito M. Blood flow of peripheral nerve effects of dissection, stretching and compression. J Hand Surg Br 1985;11B:10-4.

Richard FE, Wayne AH, Neural Mobilization: A Systematic Review of Randomized Controlled Trials with an Analysis of Therapeutic Efficacy. J Man ManipTher.2009; 16: 8-22.

Downloads

Published

08/01/2013

Issue

Vol. 3 No. 1 (2013)

Section

Literature Reviews

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Creative Commons License

How to Cite

1.
Martins Lima E, Cavalcante DM, Fernandes de Oliveira IAV, Santos Pinheiro ES dos, Baptista AF, Blanco Martinez AM. NEURODYNAMIC MOBILIZATION AND PERIPHERAL NERVE REGENERATION: LITERATURE REVIEW. Rev Pesq Fisio [Internet]. 2013 Aug. 1 [cited 2024 Nov. 21];3(1). Available from: https://journals.bahiana.edu.br/index.php/fisioterapia/article/view/108

Most read articles by the same author(s)

1 2 > >>