REGULAR PRATICE FOOTBALL: THE HIGH PERFORMACE OF THIS SPORTIS IS RELATED TO GENETIC DAMAGE?

Authors

  • Marcelo Trotte Motta Grupo de Fisioterapia e Pesquisa Cardiovascular da Faculdade Social da Bahia, Salvador, BA, Brasil. Universidade Estadual de Feira de Santana, Feira de Santana, BA, Brasil.
  • Filipe Ferrari Ribeiro de Lacerda Grupo de Fisioterapia e Pesquisa Cardiovascular da Faculdade Social da Bahia, Salvador, BA, Brasil.
  • Alan Carlos Nery dos Santos Grupo de Pesquisa Ciências da Saúde em Fisioterapia. Universidade Salvador - UNIFACS, Salvador, BA, Brasil.
  • Ana Marice Teixeira Ladeia Escola Bahiana de Medicina e Saúde Pública, Salvador, BA, Brasil.
  • Jefferson Petto rupo de Fisioterapia e Pesquisa Cardiovascular da Faculdade Social da Bahia, Salvador, BA, Brasil. Programa de Pós-Graduação Stricto Sensu em Medicina e Saúde Humana da Escola Bahiana de Medicina e Saúde Pública, Salvador, BA, Brasil.

DOI:

https://doi.org/10.17267/2238-2704rpf.v7i1.1186

Keywords:

Football, DNA Damage, Free Radicals, Physical and Rehabilitation Medicine

Abstract

Introduction: Studies indicate that moderate intensity physical exercises, especially those of endurance, have a preventive effect on cardiovascular diseases. However, other studies show that exercise when practiced at high intensity induces the occurrence of genetic damage, which, in turn, are associated with the malignant transformation process. Objective: To test the hypothesis that football athletes present occurrence of chromosomal damage with greater appearance of micronuclei compared to sedentary individuals or non-professional practitioners of physical exercise. Methods: The sample included only males, 18-38 years old, non-smokers, divided into three groups: Group I, formed by football athletes, members of the same club, subjected to intense physical exercise; Group II, consisting of students from the State University of Feira de Santana, enrolled in the Exercise Program Physical Activity Laboratory; and Group III, formed by individuals of sedentary habits. Results: A total of 52,000 cells were analyzed. The analysis of the differences between the averages calculated micronuclei done using analysis of variance with a classification criterion, showed no significant difference between the group studied (F2,49 = 0.11, p = 0.88). Conclusion: In conclusion, our study showed that the practice of football by high-intensity professional athletes does not cause damage to DNA.

Downloads

Download data is not yet available.

Author Biographies

  • Marcelo Trotte Motta, Grupo de Fisioterapia e Pesquisa Cardiovascular da Faculdade Social da Bahia, Salvador, BA, Brasil. Universidade Estadual de Feira de Santana, Feira de Santana, BA, Brasil.
    Bacharel em Educação Física. Mestre em Biotecnologia. Professor da Universidade Estadual de Feira de Santana e da Faculdade Social da Bahia, Salvador, Bahia, Brasil.
  • Filipe Ferrari Ribeiro de Lacerda, Grupo de Fisioterapia e Pesquisa Cardiovascular da Faculdade Social da Bahia, Salvador, BA, Brasil.
    Bacharel em Educação Física pela Faculdade Social da Bahia, Salvador, Bahia, Brasil.
  • Alan Carlos Nery dos Santos, Grupo de Pesquisa Ciências da Saúde em Fisioterapia. Universidade Salvador - UNIFACS, Salvador, BA, Brasil.
    Fisioterapeuta. Mestre em Medicina e Saúde Humana. Professor na Universidade Salvador (UNIFACS), Salvador, Bahia, Brasil.
  • Ana Marice Teixeira Ladeia, Escola Bahiana de Medicina e Saúde Pública, Salvador, BA, Brasil.
    Médica. Doutora em Medicina e Saúde. Professora na Escola Bahiana de Medicina e Saúde Pública, Salvador, Bahia, Brasil.
  • Jefferson Petto, rupo de Fisioterapia e Pesquisa Cardiovascular da Faculdade Social da Bahia, Salvador, BA, Brasil. Programa de Pós-Graduação Stricto Sensu em Medicina e Saúde Humana da Escola Bahiana de Medicina e Saúde Pública, Salvador, BA, Brasil.
    Fisioterapeuta. Doutor em Medicina e Saúde Humana. Professor na Escola Bahiana de Medicina e Saúde Humana. Presidente da Comissão Científica do Departamento de Fisioterapia da Sociedade Brasileira de Cardiologia, Salvador, Bahia, Brasil.

References

Wolff G.; Toborek M. Targeting the Therapeutic Effects of Exercise on Redox-Sensitive Mechanism in the Vascular Endothelium During Tumor Progression. IUBMB Life. 2013;65(7):565-571.

Cuevas M.J.; Almar M.; García-Glez J.C.; García-López D.; De Paz J.A.; Alvear-Ordenes I. et al. Changes in oxidative stress markers and NF-kappaB activation induced by sprint exercise. Free Radic Res. 2005; 39(4):431-9.

Westerlind K.C. Physical activity and cancer prevention-mechanisms. Med Sci Sports Exerc. 2003; 35(11):1834-1840.

Yavari A.; Javadi M.; Mirmiran P.; Bahadoran Z. Exercise-Induced Oxidative Stress and Dietary Antioxidants. Asian J Sports Med. 2015; 6(1):1-7.

Kehrer J.P.; Klotz L.O. Free radicals and related reactive species as mediators of tissue injury and disease: implications for Health. Crit Rev Toxicol. 2015; 45(9):765-798.

Mello T.; Zanieri F.; Ceni E.; Galli A. Oxidative Stress in the Healthy and Wounded Hepatocyte: A Cellular Organelles Perspective. Oxid Med Cell Longev. 2016; 2016:1-15.

Singaraju M. Singaraju S.; Parwani R.; Wanjari S. Cytogenetic biomonitoring in petrol station attendants: A micronucleus study. J Cytol. 2012; 29(1):1-5.

De Carvalho C.A.P. Frequência de micronúcleos em células esfoliadas da mucosa bucal de pacientes obesos, 96f. Tese (Doutorado em Odontologia) - Faculdade de Odontologia de Bauru, Universidade de São Paulo, Bauru, 2012.

Schiffl C.; Zieres C.; Zankl H. Exhaustive physical exercise increases frequency of micronuclei. Mutat Res. 1997; 389(2-3):243-246.

Pereira B.C.; Pauli J.R.; Antunes L.M.; de Freitas E.C.; de Almeida M.R.; de Paula Venâncio V. et al. Overtraining is associated with DNA damage in blood and skeletal muscle cells of Swiss mice. BMC Physiol. 2013; 13(11):1-9.

Bangsbo J. The physiology of soccer--with special reference to intense intermittent exercise. Acta Physiol Scand Suppl. 1994; 619:1-15.

Impellizzeri F.M.; Rampinini E.; Marcora S.M. Physiological assessment of aerobic training in soccer. J Sports Sci. 2005; 23:583-592.

Fenech M. The in vitro micronucleus technique. Mutat Res. 2000; 455:81-95.

Fenech M.; Chang W.P.; Kirsch-Volders M.; Holland N.; Bonassi S.; Zeiger E. et al. HUman MicroNucleus project. HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures. Mutat Res. 2003; 534:65-75.

Hartmann A.; Pfuhler S.; Dennog C.; Germadnik D.; Pilger A.; Speit G. Exercise-induced DNA effects in human leukocytes are not accompanied by increased formation of 8-hydroxy-2'-deoxyguanosine or induction of micronuclei. Free Radic Biol Med. 1998; 24:245-251.

Umegaki K.; Higuchi M.; Inoue K.; Esashi T. Influence of one bout of intensive running on lymphocyte micronucleus frequencies in endurance-trained and untrained men. Int J Sports Med. 1998; 19:581-585.

Knez W.L.; Jenkins D.G.; Coombes J.S. Oxidative stress in half and full Ironman triathletes. Med Sci Sports Exerc. 2007; 39(2):283-288.

Schneider C.D.; de Oliveira A.R. Radicais livres de oxigênio e exercício: mecanismos de formação e adaptação ao treinamento físico. Rev Bras Med Esporte. 2004; 10(4):308-313.

Reichhold S.; Neubauer O.; Ehrlich V.; Knasmüller S.; Wagner KH. No acute and persistent DNA damage after an Ironman triathlon. Cancer Epidemiol Biomarkers Prev. 2008; 17(8):1913-1919.

Pittaluga M.; Parisi P.; Sabatini S.; Ceci R.; Caporossi D.; Valeria Catani M. et al. Cellular and biochemical parameters of exercise-induced oxidative stress: relationship with training levels. Free Radic Res. 2006; 40:607-614.

Kassie F.; Parzefall W.; Knasmuller S. Single cell gel electrophoresis assay: a new technique for human biomonitoring studies. Mutat Res/Res Mutat Res. 2000; 463:13-31.

Sahlin K.; Shabalina I.G.; Mattsson C.M.; Bakkman L.; Fernström M.; Rozhdestvenskaya Z. et al. Ultraendurance exercise increases the production of reactive oxygen species in isolated mitochondria from human skeletal muscle. J Appl Physiol. 2010; 108(4):780-787.

Franzke B.; Halper B.; Hofmann M.; Oesen S.; Peherstorfer H.; Krejci K. et al. The influence of age aerobic fitness on chromosomal damage in Austrian institutionalized elderly. Mutagenesis. 2014; 29(6):441-445.

York T.P.; Brumelle J.; Juusola J.; Kendler K.S.; Eaves L.J.; Amstadter A.B. et al. Increased Frequency of Micronuclei in Adults with a History of Childhood Sexual Abuse: A Discordant Monozygotic Twin Study. PLoS ONE. 2013; 8(1):1-8.

Franzke B.; Halper B.; Hofmann M.; Oesen S.; Jandrasits W.; Baierl A. et al. The impact of six months strength training, nutritional supplementation or cognitive training on DNA damage in institutionalized elderly. Mutagenesis. 2015; 30(1):147-153.

Downloads

Published

02/21/2017

Issue

Vol. 7 No. 1 (2017)

Section

Original Articles

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Creative Commons License

How to Cite

1.
Motta MT, de Lacerda FFR, dos Santos ACN, Ladeia AMT, Petto J. REGULAR PRATICE FOOTBALL: THE HIGH PERFORMACE OF THIS SPORTIS IS RELATED TO GENETIC DAMAGE?. Rev Pesq Fisio [Internet]. 2017 Feb. 21 [cited 2024 May 17];7(1):36-45. Available from: https://journals.bahiana.edu.br/index.php/fisioterapia/article/view/1186

Most read articles by the same author(s)

<< < 1 2