Clinical outcomes of neurological patients with and without prolonged mechanical ventilation

Authors

DOI:

https://doi.org/10.17267/2238-2704rpf.v11i4.4025

Keywords:

Artificial Respiration. , Intensive Care Units. , Respirator., Weaning.

Abstract

INTRODUCTION: Patients with neurological diseases on mechanical ventilation (MV) are at increased risk of prolonged MV (PMV) due to lowered level of consciousness, abnormal breathing patterns, and inability to protect the airways caused by neurological damage. OBJECTIVE: To compare clinical outcomes of neurological patients with or without PVM. MATERIALS AND METHODS: This was a retrospective observational documentary study carried out in the neurological ICU of a teaching hospital. The following were collected: age, gender, the pathology that led to hospitalization, presence of comorbidities, simplified acute physiology score (SAPS III), the incidence of PMV, length of stay on MV, length of stay in the ICU, and outcome discharge or death in the unit. Patients were divided into two groups according to the duration of MV, the PMV group and the non-PMV group. RESULTS: A total of 212 patients were included, the most prevalent diagnosis in the PMV group was brain tumor resection (27.5%), and in the group without PMV, it was traumatic brain injury (18%). It was found that 10% of these evolved to PMV. There was a prevalence of males in both groups. The PMV group had a significantly higher SAPS III score (p=0.003) than the group without PMV. The PMV group remained significantly longer (p<0.0001) in MV and ICU stay in days than the group without PMV. There was no significant difference (p=1.00) in the ICU outcome of discharge or death between the groups with and without PMV. CONCLUSION: The group of patients under PMV spent more time on invasive ventilatory support and remained in the ICU longer than those without PMV. There were no statistical differences in the ICU mortality outcome.

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References

Santos CD, Nascimento ERPD, Hermida PMV, Silva TG, Galetto SGDS, Silva NJCD, et al. Good nursing practices towards patients on invasive mechanical ventilation in hospital emergency. Esc Anna Nery. 2020;24(2):1-7. https://doi.org/10.1590/2177-9465-EAN-2019-0300

Kutchak FM, Debesaitys AM, Rieder MDM, Meneguzzi C, Skueresky AS, Forgiarini-Junior LA, et al. Reflex cough PEF as a predictor of successful extubation in neurological patients. J Bras Pneumol. 2015;41(4):358-64. https://doi.org/10.1590/S1806-37132015000004453

MacIntyre NR, Epstein SK, Carson S, Scheinhorm D, Christopher K, Muldoon S, et al. Management of patients requiring prolonged mechanical ventilation: report of a NAMDRC consensus conference. Chest. 2005;128(6):3937-54. https://doi.org/10.1378/chest.128.6.3937

Muzaffar SN, Gurjar M, Baronia AK, Azim A, Mishra P, Poddar B. Predictors and pattern of weaning and long-term outcome of patients with prolonged mechanical ventilation at an acute intensive care unit in North India. Rev Bras ter intensiva [Internet]. 2017;29(1):23-33. Available from: https://www.scielo.br/j/rbti/a/3JLV5hPw4mdRFyVDsRtz49S/?lang=pt

Loss SH, Oliveira RP, Maccari JG, Savi A, Boniatti MM, Hetzel MP, et al. The reality of patients requiring prolonged mechanical ventilation: a multicenter study. Rev Bras Ter Intensiva. 2015;27(1):26-35. https://doi.org/10.5935/0103-507X.20150006

Chelluri L, Im KA, Belle SH, Schulz R, Rotondi AJ, Donahoe MP, et al. Long-term mortality and quality of life after prolonged mechanical ventilation. Crit Care Med. 2004;32(1):61-9. https://doi.org/10.1097/01.CCM.0000098029.65347.F9

Sun Y, Li S, Wang S, Li C, Li G, Xu J, et al. Predictors of 1-year mortality in patients on prolonged mechanical ventilation after surgery in intensive care unit: a multicenter, retrospective cohort study. BMC Anesthesiol. 2020;20(1):44. https://doi.org/10.1186/s12871-020-0942-0

MacIntyre NR, Epstein SK, Carson S, Scheinhorn D, Christopher K, Muldoon S. Management of patients requiring prolonged mechanical ventilation: report of a NAMDRC consensus conference. Chest. 2005;128(6):3937-54. https://doi.org/10.1378/chest.128.6.3937

Gracey DR, Hardy DC, Koenig GE. The chronic ventilator-dependent unit: a lower-cost alternative to intensive care. Mayo Clin Proc. 2000;75(5):445-9. https://doi.org/10.4065/75.5.445

Bureau of Data Management and Strategy. 100% MEDPAR inpatient hospital fiscal year 1998, 6/99 update. United States Health Care Finance Administration. Washington, DC: US Government Printing Office; 1999.

Gutiérrez EP, Díaz JSS, Hernandez RF, Rodriguez EAM, Peniche KG, Gutiérrez SPD, et al. Los predictores en el retiro de la ventilación mecánica resultan suficientes para el paciente neurocrítico? Med Int México. 2017;33(5):675-91. https://doi.org/10.24245/mim.v33i5.1561

Sousa ACM, Sanchez LCA, Ferreira LL. Clinical outcomes of patients undergoing invasive mechanical ventilation in a neurosurgical ICU. ASSOBRAFIR Ciênc. 2021;12:e42286. https://doi.org/10.47066/2177-9333.AC.2020.0021

Piotto RF, Ferreira FB, Colósimo FC, Silva GS, Sousa AG, Braile DM. Independent predictors of prolonged mechanical ventilation after coronary artery bypass surgery. Rev Bras Cir Cardiovasc [Internet]. 2012;27(4):520-8. Disponível em: https://www.scielo.br/j/rbccv/a/xcJHcfcPJKQwncnWrqdBcWD/?format=pdf&lang=en

Silva Júnior JM, Malbouisson LMS, Nuevo HL, Barbosa LGT, Maruabayeshi LY, Teixeira IC, et al. Applicability of the simplified acute physiology score (SAPS 3) in Brazilian hospitals. Rev Bras Anestesiol. 2010;60(1):20-31. https://doi.org/10.1590/S0034-70942010000100003

Le Gall JR, Loirat P, Alperovitch A, Glaser P, Granthil C, Mathieu D, et al. A simplified acute physiology score for ICU patients. Crit Care Med. 1984;12(11):975-7. https://doi.org/10.1097/00003246-198411000-00012

Damuth E, Mitchell JA, Bartock JL, Roberts BW, Trzeciak S. Long-term survival of critically ill patients treated with prolonged mechanical ventilation: a systemic review and meta-analysis. Lancet Respir Med. 2015;3(7):544-53. https://doi.org/10.1016/S2213-2600(15)00150-2

Lone NI, Walsh TS. Prolonged mechanical ventilation in critically ill patients: epidemiology, outcomes and modelling the potential cost consequences of establishing a regional weaning unit. Crit Care. 2011;15(2):R102. https://doi.org/10.1186/cc10117

Estenssoro E, González F, Laffaire E, Canales H, Sáenz G, Reina R, et al. Shock on admission day is the best predictor of prolonged mechanical ventilation in the ICU. Chest. 2005;127(2):598-603. https://doi.org/10.1378/chest.127.2.598

Rish MA, Kashyap R, Wilson G, Schenck L, Hocker S. Association of extubation failure and functional outcomes in patients with acute neurologic illness. Neurocrit Care. 2016;24(6):217-25. https://doi.org/10.1007/s12028-015-0156-3

Scheinhorn DJ, Hassenpflug MS, Votto JJ, Chao DC, Epstein SK, et al. Post-ICU mechanical ventilation at 23 long-term care hospitals: a multicenter outcomes study. Chest. 2007;131(1):85-93. https://doi.org/10.1378/chest.06-1081

Scheinhorn DJ, Hassenpflug MS, Votto JJ, Chao DC, Epstein SK, Doig GS, et al. Ventilator-dependent survivors of catastrophic illness transferred to 23 long-term care hospitals for weaning from prolonged mechanical ventilation. Chest. 2007;131(1):76-84. https://doi.org/10.1378/chest.06-1079

Bigatello LM, Stelfox HT, Berra L, Schmidt U, Gettings EM. Outcome of patients undergoing prolonged mechanical ventilation after critical illness. Crit Care Med. 2007;35(11):2491-7. https://doi.org/10.1097/01.CCM.0000287589.16724.B2

Huang CT, Yu CJ. Conventional weaning parameters do not predict extubation outcome in intubated subjects requiring prolonged mechanical ventilation. Respir Care. 2013;58(8):1307-14. https://doi.org/10.4187/respcare.01773

Jubran A, Grant BJ, Duffner LA, Collins EG, Lanuza DM, Hoffman LA, et al. Effect of pressure support vs unassisted breathing through a tracheostomy collar on weaning duration in patients requiring prolonged mechanical ventilation: a randomized trial. JAMA. 2013;309(7):671-7. https://doi.org/10.1001/jama.2013.159

Robertson TE, Sona C, Schallom L, Buckles M, Cracchiolo L, Schuerer D, et al. Improved extubation rates and earlier liberation from mechanical ventilation with implementation of a daily spontaneous-breathing trial protocol. J Am Coll Surg. 2008;206(3):489-95. https://doi.org/10.1016/j.jamcollsurg.2007.08.022

Published

10/22/2021

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Original Articles

How to Cite

1.
Ferreira LL, Sousa ACM, Sanchez LCA. Clinical outcomes of neurological patients with and without prolonged mechanical ventilation. Rev Pesq Fisio [Internet]. 2021 Oct. 22 [cited 2024 Nov. 23];11(4):671-8. Available from: https://journals.bahiana.edu.br/index.php/fisioterapia/article/view/4025