Association between functional mobility, muscle strength and cognitive performance in older adults with type 2 diabetes mellitus: a cross-sectional study

Authors

DOI:

https://doi.org/10.17267/2238-2704rpf.2026.e6519

Keywords:

Diabetes Mellitus, Muscle Strength, Mobility Limitation, Cognition

Abstract

INTRODUCTION: Elderly individuals with Type 2 Diabetes Mellitus (T2DM) exhibit greater frailty and reduced functional capacity due to sarcopenia, in addition to senescence encompassing cognitive deficits in this population. OBJECTIVE: To correlate functional mobility with physical performance and cognitive capacity in elderly men with T2DM. METHODS: This cross-sectional study included 62 elderly men (65–79 years old) with T2DM, residents of São Paulo and its metropolitan region, who were participants in a project on protein supplementation and resistance training (CAAE 39202214.8.0000.0065). All participants provided written informed consent. Mobility, handgrip strength, functional capacity, and cognitive function were assessed. RESULTS: The sample showed a high prevalence of musculoskeletal pain (66.1%), falling (22.6%), and higher education level (66.1%). In elderly men with T2DM (n = 62), significant correlations were observed in functional mobility. Dual-task mobility correlated with the language domain (p = 0.014; r = −0.346). Handgrip strength of the non-dominant hand correlated with mobility (p = 0.017; r = 0.335). Functional capacity and cognitive function presented a strong correlation with mobility under dual-task conditions (p = 0.003; r = −0.422). CONCLUSION: In elderly men with T2DM, functional mobility demonstrated significant associations with the cognitive component of language and with functional capacity. Additionally, non-dominant handgrip strength showed a positive correlation with simple functional mobility. Longitudinal studies and randomized clinical trials are required to establish causal relationships and to investigate the observed associations with greater robustness.

Downloads

Download data is not yet available.

References

1. American Diabetes Association Professional Practice Committee for Diabetes. Introduction and Methodology: Standards of Care in Diabetes—2026. Diabetes Care. 2026;49(Suppl. 1):S1–5. https://doi.org/10.2337/dc26-SINT

2. American Diabetes Association (ADA). 2. Classification and Diagnosis of Diabetes. Diabetes Care. 2017;40(Suppl. 1):S11–24. https://doi.org/10.2337/dc17-S005

3. Fragala MS, Cadore EL, Dorgo S, Izquierdo M, Kraemer WJ, Peterson MD, et al. Resistance Training for Older Adults: Position Statement From the National Strength and Conditioning Association. J Strength Cond Res. 2019;33(8):2019–52. https://doi.org/10.1519/JSC.0000000000003230

4. Silveira MB, Filippin LI. The Timed Up and Go as a screening tool for fragility in physically active elderly. Cad Saude Colet. 2017;25(4):389–93. https://doi.org/10.1590/1414-462x201700040251

5. Figueiredo IM, Sampaio RF, Mancini MC, Silva FCM, Souza MAP. Test of grip strength using the Jamar dynamometer. Acta Fisiátrica. 2007;14(2):104-10. https://doi.org/10.5935/0104-7795.20070002

6. Garcia PA, Dias JMD, Dias RC, Santos P, Zampa CC. A study on the relationship between muscle function, functional mobility and level of physical activity in community-dwelling elderly. Rev Bras Fisioter. 2011;15(1):15–22. Cited: PMID: 21519713.

7. Silva CFR, Ohara DG, Matos AP, Pinto ACPN, Pegorari MS, Pegorari MS. Short Physical Performance Battery as a Measure of Physical Performance and Mortality Predictor in Older Adults: A Comprehensive Literature Review. Int J Environ Res Public Health. 2021;18(20):10612. https://doi.org/10.3390/ijerph182010612

8. Lourenço RA, Veras RP. Mini-Mental State Examination:

psychometric characteristics in elderly outpatients. Rev Saude Publica. 2006;40(4):712–9. https://doi.org/10.1590/S0034-89102006000500023

9. Souza CC, Valmorbida LA, Oliveira JP, Borsatto AC, Lorenzini M, Knorst MR, et al. Functional mobility in institutionalized and non-institutionalized elderly. Rev Bras Geriatr Gerontol. 2013;16(2):285–93. https://doi.org/10.1590/S1809-98232013000200008

10. Lopes RMF, Nascimento RFL, Esteves CS, Iatchac FO, Argimon IIL. Cognition and type 2 diabetes in the elderly. Cien Cogn [Internet]. 2011;16(3):095–108. Disponível em: https://pepsic.bvsalud.org/scielo.php?script=sci_arttext&pid=S1806-58212011000300009

11. Oliveira PP, Fachin SM, Tozatti J, Ferreira MC, Marinheiro LPF. Comparative analysis of risk for falls in patients with and without type 2 diabetes mellitus. Rev Assoc Med Bras. 2012;58(2):234–9. https://doi.org/10.1590/S0104-42302012000200021

12. Ferreira MC, Tozatti J, Fachin SM, Oliveira PP, Santos RF, Silva MER. Reduction of functional mobility and cognitive capacity in type 2 diabetes mellitus. Arq Bras Endocrinol Metab. 2014;58(9):946–52. https://doi.org/10.1590/0004-2730000003097

13. Mermerkaya G, Mermerkaya HH, Ozkan Sevencan N, Vardar Yagli N, Saglam M. Cognitive and motor dual-task performance in older adults with prediabetes and type 2 diabetes mellitus: A cross-sectional study. Medicine. 2025;104(38):e44792. https://doi.org/10.1097/MD.0000000000044792

14. Chua KY, Tan KB, Tong R, Barrenetxea J, Koh WP, Chen C. Relationship between handgrip strength and timed up-and-go test on hospitalization costs in older adults: a population-based study. BMC Public Health. 2025;25(1):290. https://doi.org/10.1186/s12889-025-21489-x

Published

06/10/2026

Issue

Section

Original Articles

How to Cite

1.
Moreira GB, de Sena HB, Bezerra ML, Machado-Lima A, Alonso AC, Brech GC, et al. Association between functional mobility, muscle strength and cognitive performance in older adults with type 2 diabetes mellitus: a cross-sectional study. Rev Pesq Fisio [Internet]. 2026 Jun. 10 [cited 2026 Jun. 13];16:e6519. Available from: https://journals.bahiana.edu.br/index.php/fisioterapia/article/view/6519