Left ventricular ejection fraction in individuals with heart failure and associated factors

Authors

DOI:

https://doi.org/10.17267/2317-3378rec.2024.e5754

Keywords:

Heart Failure, Pharmacological Treatment, Ventricular Ejection Fraction, Risk Factors

Abstract

OBJECTIVE: To verify the relationship of modifiable risk factors, clinical complications and drug therapy with left ventricular ejection fraction (LVEF) in individuals with heart failure (HF). METHODS: Cross-sectional study with secondary data from the matrix study Cerebral infarction in patients with heart failure: associated characteristics and left atrial function. The sample comprised 75 adult individuals treated at a reference outpatient clinic in Salvador, Bahia. LVEF groups were classified: reduced LVEF (LVEFr) ≤ 40%, intermediate LVEF (LVEFi) 40-49%, and preserved LVEF (LVEFp) ≥50%. An analysis was conducted using SPSS software and considered statistical significance p≤0.05. RESULTS: The sample had an average age of 62±10 years; the majority were men n=42 (56%), functional class II/IV n=41 (54.7%) and of idiopathic etiology n=33 (44%). LVEF and LVEFp were similar n=31 (41%), followed by LVEFi n=13 (18%). The LVEF subgroups were related to Diabetes Mellitus (DM) as a risk factor (p=0.049), Cerebral Vascular Accident (CVA) as a complication (p=0.001), drug therapy with beta-blockers (p=0.004) and Converting Enzyme Inhibitors of Angiotensin (ACEI/ARB) (p=0.007). CONCLUSION: DM as a risk factor, stroke as a complication, and beta-blocker medications and ACE inhibitors/ARBs are related to LVEF in individuals with HF.

Downloads

Download data is not yet available.

References

(1) Rohde LEP, Montera MW, Bocchi EA, Clausell NO, Albuquerque DC, Rassi S, et al. Diretriz Brasileira de Insuficiência Cardíaca Crônica e Aguda. Arq Bras Cardiol. 2018;111(3):436–539. https://doi.org/10.5935/abc.20180190

(2) Fernandes ADF, Fernandes GC, Mazza MR, Knijnik LM, Fernandes GS, Vilela AT, et al. A 10-year trend analysis of heart failure in the less developed Brazil. Arq Bras Cardiol. 2020;114(2):222–31. https://doi.org/10.36660/abc.20180321

(3) Ministério da saúde. DATASUS [Internet]. Brasília, DF: Ministério da Saúde; 2020. Available from: http://tabnet.datasus.gov.br/cgi/deftohtm.exe?sim/cnv/obt10uf.def

(4) Cestari VRF, Garces TS, Sousa GJB, Maranhão TA, Neto JDS, Pereira MLD, et al. Spatial Distribution of Mortality for Heart Failure in Brazil, 1996 – 2017. Arq Bras Cardiol. 2022;118(1):41–51. https://doi.org/10.36660/abc.20201325

(5) Silva-Cardoso J, Brás D, Canário-Almeida F, Andrade A, Oliveira L, Pádua F, et al. Neurohormonal modulation: The new paradigm of pharmacological treatment of heart failure. Revista Portuguesa de Cardiologia. 2019;38(3):175–85. https://doi.org/10.1016/j.repc.2018.10.011

(6) Cardoso J, Espíndola MD, Cunha M, Netto E, Cardoso C, Novaes M, et al. Is current drug therapy for heart failure sufficient to control the heart rate of patients? Arq Bras Cardiol. 2020;115(6):1063-9. https://doi.org/10.36660/abc.20190090

(7) Francisco PMSB, Assumpção D, Borim FSA, Senicato C, Malta DC. Prevalence and co-occurrence of modifiable risk factors in adults and older people. Rev Saude Publica. 2019;53:1–13. https://doi.org/10.11606/S1518-8787.2019053001142

(8) Van Deursen VM, Damman K, Van Der Meer P, Wijkstra PJ, Luijckx GJ, Van Beek A, et al. Comorbidities in Heart Failure. Heart Fail Rev. 2014;19(2):163–72. https://doi.org/10.1007/s10741-012-9370-7

(9) Conde-Martel A, Hernández-Meneses M. Prevalence and prognostic meaning of comorbidity in heart failure. Rev Clin Esp. 2016;216(4):222–8. https://doi.org/10.1016/j.rce.2015.08.005

(10) Barbosa CC, Perinote LCSC, Gomes RC, Oliveira FT, Costa JS. Cuidados de enfermagem no paciente com insuficiência cardíaca congestiva descompensada. Brazilian Journal of Health Review. 2024;7(2):e69175. https://doi.org/10.34119/bjhrv7n2-442

(11) McDonagh TA, Metra M, Adamo M, Baumbach A, Böhm M, Burri H, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2021;42(36):3599–726. https://doi.org/10.1093/eurheartj/ehab368

(12) Khan SS, Beach LB, Yancy CW. Sex-Based Differences in Heart Failure: JACC Focus Seminar 7/7. Journal of the American College of Cardiology. Elsevier Inc. 2022;79(15):1530–41. https://doi.org/10.1016/j.jacc.2022.02.013

(13) Huo X, Pu B, Wang W, Peng Y, Li J, Lei L, et al. New York Heart Association Class and Kansas City Cardiomyopathy Questionnaire in Acute Heart Failure. JAMA Netw Open. 2023;6(10):e2339458. https://doi.org/10.1001/jamanetworkopen.2023.39458

(14) Nunes MCP, Beaton A, Acquatella H, Bern C, Bolger AF, Echeverría LE, et al. Chagas Cardiomyopathy: An Update of Current Clinical Knowledge and Management: A Scientific Statement From the American Heart Association. Circulation. 2018;138(12):e169–209. https://doi.org/10.1161/CIR.0000000000000599

(15) Braga JCV, Reis F, Aras R, Dantas Costa N, Bastos C, Silva R, et al. Clinical and therapeutics aspects of heart failure due to Chagas disease. Arq Bras Cardiol. 2006;86(4):296-301. https://doi.org/10.1590/S0066-782X2006000400010

(16) Mentz RJ, Kelly JP, von Lueder TG, Voors AA, Lam CSP, Cowie MR, et al. Noncardiac Comorbidities in Heart Failure With Reduced Versus Preserved Ejection Fraction. J Am Coll Cardiol. 2014;64(21):2281–93. https://doi.org/10.1016/j.jacc.2014.08.036

(17) Pereira AWS, Miranda BCB, Pereira BWS, Coutinho RET. Arterial hypertension and heart failure: critical analysis of new drugs. Revista Brasileira de Hipertensão. 2021;28(1):27–34. https://doi.org/10.47870/1519-7522/2021280127-34

(18) Barkhudaryan A, Doehner W, Scherbakov N. Ischemic stroke and heart failure: Facts and numbers. An update. Journal of Clinical Medicine. 2021;10(5);1–14. https://doi.org/10.3390/jcm10051146

(19) Di Tullio MR, Qian M, Thompson JLP, Labovitz AJ, Mann DL, Sacco RL, et al. Left Ventricular Ejection Fraction and Risk of Stroke and Cardiac Events in Heart Failure: Data from the Warfarin Versus Aspirin in Reduced Ejection Fraction Trial. Stroke. 2016;47(8):2031–7. https://doi.org/10.1161/STROKEAHA.116.013679

(20) Adelborg K, Szépligeti S, Sundbøll J, Horváth-Puhó E, Henderson VW, Ording A, et al. Risk of Stroke in Patients with Heart Failure: A Population-Based 30-Year Cohort Study. Stroke. 2017;48(5):1161–8. https://doi.org/10.1161/STROKEAHA.116.016022

(21) Kim W, Kim EJ. Heart failure as a risk factor for stroke. Journal of Stroke. 2018;20(1):33–45. https://doi.org/10.5853/jos.2017.02810

(22) Malgie J, Clephas PRD, Brunner-La Rocca HP, de Boer RA, Brugts JJ. Guideline-directed medical therapy for HFrEF: sequencing strategies and barriers for life-saving drug therapy. Heart Failure Reviews. Springer. 2023;28:1221–34. https://doi.org/10.1007/s10741-023-10325-2

(23) Liu B, Zhang R, Zhang A, Wang G, Xu J, Zhang Y, et al. Effectiveness and safety of four different beta-blockers in patients with chronic heart failure. MedComm. 2023;4(1):e199. https://doi.org/10.1002/mco2.199

(24) Patel AH, Natarajan B, Pai RG. Current Management of Heart Failure with Preserved Ejection Fraction. International Journal of Angiology. 2022;31(3):166–78. https://doi.org/10.1055/s-0042-1756173

(25) Hikoso S, Kida H, Sunaga A, Nakatani D, Okada K, Dohi T, et al. β-blockers may be detrimental in frail patients with heart failure with preserved ejection fraction. Clinical Research in Cardiology. 2023;113:842–855. https://doi.org/10.1007/s00392-023-02301-5

(26) Meyer M, Du Fay Lavallaz J, Benson L, Savarese G, Dahlström U, Lund LH. Association Between β-Blockers and Outcomes in Heart Failure With Preserved Ejection Fraction: Current Insights From the SwedeHF Registry. J Card Fail. 2021;27(11):1165–74. https://doi.org/10.1016/j.cardfail.2021.04.015

(27) Beggs SAS, Rørth R, Gardner RS, Mcmurray JJV. Anticoagulation therapy in heart failure and sinus rhythm: a systematic review and meta-analysis. Heart. 2019;105:1325–34. https://doi.org/10.1136/heartjnl-2018-314381

(28) Shpak M, Ramakrishnan A, Nadasdy Z, Cowperthwaite M, Fanale C. Higher incidence of ischemic stroke in patients taking novel oral anticoagulants. Stroke. 2018;49(12):2851–6. https://doi.org/10.1161/STROKEAHA.118.022636

(29) Kumana CR, Cheung BMY, Siu DCW, Tse HF, Lauder IJ. Non-vitamin K Oral Anticoagulants Versus Warfarin for Patients with Atrial Fibrillation: Absolute Benefit and Harm Assessments Yield Novel Insights. Cardiovascular Therapeutics. 2016;34:100–6. https://doi.org/10.1111/1755-5922.12173

(30) Boyne JJJ, Van Asselt ADI, Gorgels APM, Steuten LMG, De Weerd G, Kragten J, et al. Cost-effectiveness analysis of telemonitoring versus usual care in patients with heart failure: The TEHAF-study. J Telemed Telecare. 2013;19(5):242–8. https://doi.org/10.1177/1357633X13495478

Published

08/13/2024

Issue

Section

Original Articles

How to Cite

1.
Oliveira Santos C, Gama GGG, de Carvalho MMCO. Left ventricular ejection fraction in individuals with heart failure and associated factors. Rev Enf Contemp [Internet]. 2024 Aug. 13 [cited 2024 Nov. 22];13:e5754. Available from: https://journals.bahiana.edu.br/index.php/enfermagem/article/view/5754

Most read articles by the same author(s)

<< < 12 13 14 15 16 17 18 19 20 21 > >>